Rapid Rx Quiz: Sexually Transmitted Infection Drug Treatments

Mary L. Windle, PharmD


November 18, 2022

According to the 2021 STI treatment guidelines from the CDC, high single-dose therapy is appropriate for a number of STIs. Azithromycin offers the convenience of a high single-dose therapy; however, more than half of patients who receive it experience diarrhea. Other common adverse effects that more than 10% of patients experience include nausea, abdominal pain, and loose stools.

Less common adverse effects include:

  • Elevated alanine transaminase, aspartate transaminase, and creatinine

  • Elevated lactate dehydrogenase and bilirubin

  • Bronchospasm

  • Dyspepsia

  • Decreased platelet count

  • Elevated serum alkaline phosphatase

  • Flatulence

  • Gastritis

  • Headache

  • Leukopenia

  • Mucositis

  • Neutropenia

  • Oral Moniliasis

  • Somnolence

  • Taste perversion

Learn more about azithromycin.


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