Skill Checkup: A 70-Year-Old Woman With History of Depression and Mild Cognitive Impairment Presents With Memory Lapses

Jasvinder P. Chawla, MD, MBA


December 22, 2022

Depression has been identified as a potential risk factor for cognitive decline and AD. Depression is the second most common neuropsychiatric symptom in patients with AD (apathy is the most common). It is also a predictor of progression from normal cognition to MCI and from MCI to dementia.

Obesity is a risk factor for AD. However, this patient does not have overweight or obesity.

Fatigue is experienced by many patients with AD and can have a detrimental impact on health and well-being; however, it is not a risk factor for the disease.

Genetic factors have been shown to play a strong role in development of AD. For example, family history of AD has been associated with increased risk for developing the disease; however, this patient does not report a positive family history.


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