Rapid Review Quiz: Chocolate and Health 

Helmi L. Lutsep, MD; Yasmine S. Ali, MD; Bradley Schwartz, DO


January 30, 2023

The COSMOS-Mind phase 3 study compared the effects of a standard multivitamin-mineral and cocoa extract on cognition in more than 2200 older participants. Participants completed tests at baseline and annually to assess cognitive abilities for 3 years. Cocoa extract had no effect on global cognition compared with placebo; however, daily multivitamin-mineral use showed significant benefits on global cognition vs placebo. Participants with a history of cardiovascular disease experienced the most pronounced beneficial effect. Researchers found similar protective effects for executive function and memory.

Learn more about mild cognitive impairment.


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