Rapid Review Quiz: Chocolate and Health 

Helmi L. Lutsep, MD; Yasmine S. Ali, MD; Bradley Schwartz, DO


January 30, 2023

A small number of patients (20) with stable coronary artery disease who were taking maintenance dual antiplatelet therapy of 75 mg/day of clopidogrel and 81 mg/day of aspirin participated in a recent study. Researchers evaluated platelet function in patients prior to initiation of and after a 1-week trial of daily consumption of 30 g/day of 65% cocoa. They then compared the results with a paired t-test.

Cocoa augmented the inhibitory effect of clopidogrel, significantly decreasing the results of VerifyNow P2Y12 reaction unit analysis. However, cocoa did not affect the inhibitory effect of aspirin based on a non-significant reduction in aspirin reaction unit assays.

Learn more about risk factors for coronary artery disease.


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