Rapid Review Quiz: Unusual Vaccine News

Michael Stuart Bronze, MD


February 13, 2023

To assess whether common adult vaccinations affect dementia risk, researchers conducted a systematic review and meta-analysis. They included 17 studies from a search of PubMed, Embase, Cochrane Library, and Web of Science, which consisted of almost 2 million participants.

Overall pooled results showed that vaccinations were associated with a 35% lower dementia risk (hazard ratio [HR], 0.65; 95% CI, 0.60-0.71, P overall effect < .001; I2 = 91.8%; P heterogeneity < .001). All types of vaccination were associated with a trend toward reduced dementia risk, with significant individual vaccinations including rabies (HR, 0.43); tetanus, diphtheria, and pertussis (HR, 0.69); herpes zoster (HR, 0.69); influenza (HR, 0.74); hepatitis A (HR, 0.78); typhoid (HR, 0.80); and hepatitis B (HR, 0.82). Gender or age did not affect this association. Individuals with more yearly influenza vaccinations and types of full vaccinations were less likely to develop dementia.

Learn more about dementia pathology.


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