Fast Five Quiz: Neurofibromatosis Type 1 Signs and Symptoms

Heidi Moawad, MD


May 02, 2023

As an autosomal dominant genetic disorder, neurofibromatosis type 1 (NF1) results from loss-of-function variants in the tumour suppressor gene NF1 and predisposes patients to tumours. NF1 is one of the most common tumour predisposition syndromes and an extremely variable multisystem disorder. The incidence of NF1 is estimated to be 1 in 3000, but this may be underestimated. Life expectancy for patients with NF1 is at least 8 years shorter for both men and women. Most individuals with NF1 are diagnosed in childhood.

How familiar are you with the signs and symptoms of NF1? Test your knowledge with this quick quiz.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.