Esophagogastroduodenoscopy (EGD) with multiple duodenal biopsies is recommended for confirmation of diagnosis in both children and adults suspected to have celiac disease (CD).
Combination of high-level tissue transglutaminase (TTG) IgA (>10× upper limit of normal) with a positive endomysial antibody (EMA) in a second blood sample is a reliable test for diagnosing CD in children.
Intestinal healing is recommended as the goal of gluten-free diet (GFD) therapy in CD patients.
Use of gluten detection devices in food or biospecimens among patients with CD is not recommended.
Consumption of gluten-free oats in the diet of those with CD is recommended.
Vaccination to prevent pneumococcal disease is recommended in patients with CD.
Immunoglobulin IgA anti-TTG antibody (TTG-IgA) is the preferred single test for the detection of CD in children younger than 2 years who are not IgA-deficient.
Testing for CD in children with IgA deficiency should be performed using IgG-based antibodies.
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Cite this: Celiac Disease Clinical Practice Guidelines (ACG, 2023) - Medscape - Mar 02, 2023.