C3 Glomerulopathy (C3G) is a group of extremely rare kidney diseases characterized by complement dysregulation in the alternative pathway and is classified into two major subgroups: C3 glomerulonephritis (C3GN) and dense deposit disease (DDD), both of which have overlapping clinical and pathologic features. The disease is largely driven by acquired factors, namely, alterations of the regulatory proteins in the complement pathways.
Patients with C3G typically present with hematuria, proteinuria, and hypertension. The disease affects all age groups, but their disease triggers differ. All patients with C3G should undergo a comprehensive complement evaluation that includes assessment of overall complement activity, measurements of serum levels of complement proteins and their split products, as well as genetic testing for autoantibodies. Treatment varies on the basis of test results.
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Cite this: A. Brent Alper. Fast Five Quiz: C3G Management - Medscape - Apr 24, 2023.