Rapid Rx Quiz: Dangerous Drug Combinations

Mary L. Windle, PharmD


March 13, 2023

Combining phosphodiesterase-5 inhibitors (eg, sildenafil, tadalafil) and oral nitrate medications is contraindicated due to risk for hypotension and other severe adverse cardiac events. However, some recent data suggest that coprescribing these drugs may be safe in certain specific situations.

Learn more about nitroglycerin.


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