Warfarin and various antimicrobials, including ciprofloxacin, azithromycin, and trimethoprim/sulfamethoxazole, may increase the risk for bleeding, especially among patients who are older or have kidney or liver impairment. These patients may require more frequent clinical monitoring to safely use both medications. Choosing agents that are less likely to affect international normalized ratio is preferred. These include clindamycin, penicillin G, and first- and fourth-generation cephalosporins.
Learn more about warfarin.
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Cite this: Mary L. Windle. Rapid Rx Quiz: Dangerous Drug Combinations - Medscape - Mar 13, 2023.