Rapid Rx Quiz: Dangerous Drug Combinations

Mary L. Windle, PharmD


March 13, 2023

Warfarin and various antimicrobials, including ciprofloxacin, azithromycin, and trimethoprim/sulfamethoxazole, may increase the risk for bleeding, especially among patients who are older or have kidney or liver impairment. These patients may require more frequent clinical monitoring to safely use both medications. Choosing agents that are less likely to affect international normalized ratio is preferred. These include clindamycin, penicillin G, and first- and fourth-generation cephalosporins.

Learn more about warfarin.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.