Fast Five Quiz: mRNA Vaccinations

Enrico Brunetti, MD


April 14, 2023

Construction of mRNA vaccines requires the insertion of an encoded antigen into a DNA template plasmid. The mRNA is then transcribed in vitro. After administration, utilizing host cell machinery, the mRNA is translated in vivo, mimicking a viral infection and eliciting a humoral and cellular immune response. A desired sequence can be rapidly designed, produced in vitro, and delivered to any type of cell.

mRNA vaccines are translated into proteins in the body of a patient. Unlike DNA-based vaccines, mRNA vaccines do not require nuclear entry nor integrate in the genome of the host cells. This makes the mRNA vaccines safer; the probability of random genome integration is virtually zero.

The mRNA COVID-19 vaccine is not contraindicated in children who are not fully developed.

In addition, mRNA vaccines are produced substantially faster compared with conventional vaccines.

Learn more about the development of mRNA vaccines.


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