Skill Checkup: A 50-Year-Old Man Who Recovered From COVID-19 Is Still Experiencing Persistent Fatigue

Enrico Brunetti, MD


May 11, 2023

A recent study published in Vaccines demonstrated that SARS-CoV-2 vaccination was well tolerated in most patients with long COVID and that the vaccines maintained good immunogenicity. At the time of the study, 30% of patients with long COVID were unvaccinated. Further, the bivalent booster is both safe and effective in patients with prior COVID-19 infection.

In a systemic review of the literature, researchers reported mixed results regarding vaccination and its effect on long COVID symptoms, with more studies favouring improved symptoms with vaccination vs worsening symptoms. According to the authors, 'Eleven studies (n=36,736 COVID-19 survivors) investigated changes in long-COVID symptoms after vaccination (infection-long-COVID-vaccine design). Seven articles showed an improvement in long-COVID symptoms at least one dose post-vaccination, while four studies reported no change or worsening in long-COVID symptoms after vaccination'.

This patient and his physician consider the bivalent vaccine.

Editor's Note: Skill Checkups are wholly fictional or fictionalized clinical scenarios intended to provide evidence-based educational takeaways.

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