Antiviral treatment is most effective in the early phase of the clinical course of COVID-19. Because this patient's symptoms started just a day ago, antiviral medication should help address the greater level of viral replication that happens during this phase.
In the later phase of the clinical course of COVID-19, the disease is driven by a hyperinflammatory state, which is when anti-inflammatory agents like corticosteroids, immunomodulating therapies or combination of the two are likely to be most effective.
Supplemental oxygen via high-flow nasal cannula is generally reserved for patients with COVID-19-associated acute hypoxemic respiratory failure with the goal of preventing escalation to mechanical ventilation.
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Cite this: Enrico Brunetti. Skill Checkup: An 18-Year-Old Woman With Fever, Headache, Malaise, Muscle Pain and Shortness of Breath - Medscape - May 11, 2023.