Fast Five Quiz: Metastatic Melanoma Treatment

Winston W. Tan, MD, FACP


May 24, 2023

National Comprehensive Cancer Network (NCCN) guidelines denote that postoperative radiation may decrease the risk for local recurrence, and that SRS is the preferred radiation approach. The brain is a common site of metastasis in malignant melanoma, and SRS is used increasingly in patients with a limited number of brain metastases (< 3). There is considerable debate as to the value of WBRT after resection or SRS in patients with melanoma brain metastases and concern about the potential long-term neurocognitive toxicity. Among other approaches, craniotomy is more invasive, and external beam radiation alone appears effective primarily in palliating symptoms.

Learn more about the treatment of brain metastases in advanced-stage melanoma.


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