Myelofibrosis is a rare, chronic BCR-ABL1-negative myeloproliferative neoplasm characterized by progressive bone marrow fibrosis, inefficient hematopoiesis, and shortened survival. The clinical manifestations include splenomegaly consequent to extramedullary hematopoiesis, cytopenias, and an array of potentially debilitating abdominal and constitutional symptoms. Dysregulated Janus kinase (JAK)-signal transducer and activator of transcription signaling underlie secondary disease-associated effects in myelofibrosis, such as myeloproliferation, constitutional symptoms, and cachexia. Common fatal complications of myelofibrosis include thrombohemorrhagic events, organ failure, and infections.
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Cite this: Anand Patel. Fast Five Quiz: Myelofibrosis Complications - Medscape - Jun 20, 2023.