C3 glomerulopathy (C3G) refers to a group of rare kidney diseases known as membranoproliferative glomerulonephritis. The group is distinguished by complement dysregulation in the glomerular microenvironment in the fluid phase, which results in complement C3 deposition in the kidney tissue. There are two major subgroups of C3G, dense deposit disease (DDD) and C3 glomerulonephritis (C3GN), both of which have overlapping clinical and pathologic features.
Diagnosis of C3G focuses on the assessment of both structural and functional abnormalities in the kidneys and includes a kidney biopsy with the demonstration of C3-dominant glomerular staining by immunofluorescence microscopy. Treatment varies, depending upon test results and patient presentation.
How much do you know about the causes of C3G? Test your knowledge with this quick quiz.
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Cite this: A. Brent Alper. Fast Five Quiz: C3 Glomerulopathy Causes - Medscape - Sep 11, 2023.