Rapid Review Quiz: Antisocial Personality Disorder

Stephen Soreff, MD


September 25, 2023

Antisocial personality disorder (ASPD) is a dysfunctional thought process focused on socially exploitative behavior and typically characterized by a patient's lack of remorse for the behaviors. It is one of the four personality disorders that the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) places into cluster B, which also includes borderline, narcissistic, and histrionic personality disorders. Both environmental factors (such as neglect and physical and sexual abuse) and genetic factors play a role in the development of ASPD, with estimates of heritability ranging from 38% to 69%. Childhood psychopathology also strongly correlates to the development of ASPD. Estimated prevalence of ASPD among the general population is about 6% in men and 2% in women. The importance of early intervention for patients with ASPD has long been recognized, but because of the relative paucity of pharmacologic treatment options for ASPD, research in this area is sparse.

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